Researchers find Gene that could be manipulated to Slow Ageing

Researchers find Gene that could be manipulated to Slow Ageing

Lately, a team of biologists from UCLA announced about discovery of a gene called AMPK that can help slow ageing process and finally, help people lead a longer life.

An experiment was carried out on fruit flies. The lab studies have led researchers to know about a cellular mechanism present inside the body. This mechanism has the ability to improve the process to flush out cellular debris that is left behind during the ageing process linked with age-related diseases.

Researchers noticed that after they activated the gene, lifespan of fruit fly increased by around one-third. A positive effect was also seen on their health as during their life extension, fruit flies remained healthy. If this life extension process is considered among humans then it means another 24 years of good health.

Senior study author, David Walker, Associate Professor at UCLA, said, "This research brings us closer to understanding aging at a cellular level and has implications for delaying the onset and slowing the progression of many of the major diseases of aging".

The UCLA research team headed by Mathew Ulgherait decided to focus on the gene for its role in improving autophagy. It is a physiological process in the body that handles the destruction of cells in the body. It maintains homeostasis for the new cell formation.

For past many years, researchers have been focussing to find ways to boost autophagy as it is quite important for anti-ageing research. With passage of time, the interest of researchers in finding ways to boost autophagy has increased, as they are now coming to know new factors that add to age-related disease.

The discovery can improve situations that lead to neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. Another notable finding was after switching off another gene, Atg1, researchers came to know that autophagy and longevity go hand in hand.


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