Amgen’s Brodalumab: Potential Treatment against Psoriatic Arthritis

Amgen’s Brodalumab: Potential Treatment against Psoriatic Arthritis

A study funded by Amgen Inc. has developed a drug called brodalumab, which appears to be quite effective in treating psoriatic arthritis. Dr. Philip Mease, a rheumatologist at Swedish Medical Center in Seattle and the lead researcher of the study said that the trials have concluded with positive outcomes.

Psoriatic arthritis is a type of arthritic inflammation that affects as many as 30% of people who have psoriasis and causes scaly red and white patches on the skin. Further, the immune system gets affected, which leads to damage of joints.

The drug brodalumab's response towards a patient is significant from the fact that there is a reduction in the swelling of patient's fingers and toes along with the betterment of the skin quality. This helps improve a condition called dactylitis, which is very common in psoriatic arthritis.

Dr. Philip Mease said, "From an efficacy point of view the drug worked". He presented 12-week data from the 168-patient trial at the meeting of the European League against Rheumatism held in Paris on Saturday. The New England Journal of Medicine has also published the detailed study results.

Brodalumab basically works by stopping a signaling pathway that plays a key role in inducing and promoting inflammatory diseases. This drug belongs to a class of drugs called IL-17 inhibitors.

This study is considered important from the point that doctors are badly looking for new treatments for psoriatic arthritis and related diseases as effectiveness of already being used drugs, which are the powerful anti-TNF drugs, has diminished over the time.


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